The damage bill from a truck crash on a major Queensland highway is expected to run into the tens of millions of dollars, and some warn it could happen again unless upgrades are fast-tracked.

A truck carrying parts of a wind turbine struck the Mount Crosby Bridge on the Warrego Highway near Ipswich about 1:40am on Friday, after reportedly failing to follow escort vehicles onto an off-ramp.

The crash forced the closure of the highway's westbound lanes for two-and-a-half days, disrupting freight and local traffic.

One lane on the overpass reopened Tuesday, but the bridge won't be able to carry heavy vehicles until permanent repairs are completed.

A Queensland police spokesperson said investigations into the crash were continuing.

The Warrego Highway is a major freight highway that links south-east Queensland to Toowoomba, the Darling Downs and Maranoa region.

It connects to other highways, connecting to Mount Isa and the Northern Territory and is a major inland freight route.

According to TMR, about 30,000 vehicles use the westbound section of the highway every day.